NO-Releasing Catheter Insert
Nytricx’s catheter insert is a novel, light-activated antimicrobial solution engineered to reduce infections and complications associated with indwelling catheters. Using a fiber optic-triggered nitric oxide release system, it delivers targeted, non-antibiotic protection against bacteria and biofilm—without altering existing catheter hardware
Controlled Nitric Oxide Delivery: Inside the Catheter Insert System
Catheter Inserter: Product Overview
The Nytricx Catheter Insert is a disposable, fiber optic-driven antimicrobial device designed to fit inside standard urinary and vascular catheters. It releases nitric oxide (NO) on demand, helping to prevent infection, biofilm formation, and blood clots—without modifying the catheter or relying on systemic antibiotics.
- Designed for: Foley catheters, central venous catheters (CVC), dialysis catheters, endotracheal tubes
- NO is released via light-activated SNAP embedded in silicone
- No antibiotic resistance risk
Wearable Antimicrobial Fiber Optic Catheter Insert
- Nitric Oxide (NO) donor SNAP is covalently linked with polydimethylsiloxane (PDMS)
- LED illumination of the fiber optic controlsreal-time NO release.
- Therapeutic levels of NO is released via photocatalysis from PACI.
- Enhanced device longevity
Scientific Highlights
- Real-time, light-controlled NO releaseusing smartphone-driven LED
- Active protectionon both extraluminal and intraluminal surfaces
- Compatible with any standard catheter lumen
Pre‑Clinical Data Snapshot
- Proven antimicrobial activity in vitro and in vivo (porcine & rodent models)
- NO release shown to be dose-controlled via light intensity
- Statistically significant log reductions in biofilm and bacterial growth (p < 0.05)
Design & Composition
- Polymer: Medical-grade PDMS (silicone) + SNAP (NO donor)
- Mechanism: Fiber optic + smartphone or wearable-connected LED
- Form: Flexible side-glow insert; replaces or augments catheter hub
- Usage: Disposable or replaceable during standard catheter maintenance
Four Core Functions of the NO-Releasing Catheter Insert
1.
Insertion
Seamless Compatibility
Slides into standard catheters with no modification.
2.
Activation
Light-Triggered NO Release
Releases NO gas when exposed to fiber optic light.
3.
Targeted Action
Dual-Surface Protection
NO targets both inner and outer catheter surfaces.
4.
Smart Control
Adjustable & Replaceable
Controlled by light intensity; easy to swap out.
- Polymer: Medical-grade PDMS (silicone) + SNAP (NO donor)
- Mechanism: Fiber optic + smartphone or wearable-connected LED
- Form: Flexible side-glow insert; replaces or augments catheter hub
- Usage: Disposable or replaceable during standard catheter maintenance
Commercial Outlook & Strategic Development
Market Opportunity
- CAUTIs and CLABSIs represent a multibillion-dollar global burden
- Universal insert compatible with urinary, vascular, dialysis, and endotracheal tubes
- Potential to dramatically reduce infection-related re-admissions and mortality
Funding Secured
- $6.2 million raised to date from non-dilutive grants: (CDC, NIH, DoD, BARDA)
- $6.3 million in NIH funding pending
Seeking Strategic Partners
Nytricx is seeking $10 million Series A funding in milestone-based tranches:
| Milestone | Use of Funds | Amount | Target Year |
|---|---|---|---|
| 1. | Finalize formulation & non-GLP safety evaluation | $2 Million | 2025 |
| 2. | GMP manufacturing & GLP toxicology studies | $4 Million | 2026 |
| 3. | Phase II clinical trials | $4 Million | 2027 |
Flexible terms available. Interested in investing or partnering?
Contact us to schedule a conversation.
Contact Us
Ronald Shebuski,
PhD, President and CEO
