NO-Releasing Catheter Insert
Nytricx catheter insert is a novel, light-activated antimicrobial device engineered to reduce infections and other complications associated with indwelling catheters. Using a fiber-optic-triggered nitric oxide release system, it delivers targeted, non-antibiotic protection against bacteria and biofilm—compatible with most standard catheters.
Controlled Nitric Oxide Delivery: Inside the Catheter Insert System
Catheter Inserter: Product Overview
The Nytricx Catheter Insert is a disposable, fiber-optic-driven antimicrobial device designed to fit inside standard urinary and vascular catheters. It releases nitric oxide (NO) based on light intensity, helping to prevent infection, biofilm formation, and blood clots—without modifying the catheter or relying on systemic antibiotics.
- Designed for: Foley catheters, central venous catheters (CVC), dialysis catheters, endotracheal tubes
- NO is released via light-activated SNAP embedded in silicone
- Limited antibiotic resistance risk
Wearable Antimicrobial Fiber Optic Catheter Insert
- Nitric Oxide (NO) donor SNAP is covalently linked with polydimethylsiloxane (PDMS)
- LED illumination of the fiber-optic controls real-time NO release
- Therapeutic levels of NO is released via photocatalysis from PDMS
- Enhanced catheter device longevity
Scientific Highlights
- Real-time, light-controlled NO release using smartphone-driven LED
- Active protection on both extraluminal and intraluminal surfaces
- Compatible with any standard catheter lumen
Pre‑Clinical Data Snapshot
- Proven antimicrobial activity in vitro and in vivo (porcine & rodent models)
- NO release shown to be dose-controlled via light intensity
- Statistically significant log reductions in biofilm and bacterial growth (p < 0.05)
Design & Composition
- Polymer: Medical-grade PDMS (silicone) + SNAP (NO donor)
- Mechanism: Fiber optic + smartphone or wearable-connected LED
- Form: Flexible side-glow insert; replaces or augments catheter hub
- Usage: Disposable or replaceable during standard catheter maintenance
Four Core Functions of the NO-Releasing Catheter Insert
Insertion
Seamless Compatibility
Activation
Light-Triggered NO Release
Targeted Action
Dual-Surface Protection
Smart Control
Adjustable & Replaceable
- Polymer: Medical-grade PDMS (silicone) + SNAP (NO donor)
- Mechanism: Fiber optic + smartphone or wearable-connected LED
- Form: Flexible side-glow insert; replaces or augments catheter hub
- Usage: Disposable or replaceable during standard catheter maintenance
Commercial Outlook & Strategic Development
Market Opportunity
- CAUTIs and CLABSIs represent a multibillion-dollar global burden
- Universal insert compatible with urinary, vascular, dialysis, and endotracheal tubes
- Potential to dramatically reduce infection-related re-admissions and mortality
Funding Secured
- $6.2 million raised to date from non-dilutive grants: (CDC, NIH, DoD, BARDA)
- $6.3 million in NIH funding pending
Seeking Strategic Partners
| Milestone | Use of Funds | Amount | Target Year |
|---|---|---|---|
| 1. | Finalize formulation & non-GLP safety evaluation | $2 Million | 2025 |
| 2. | GMP manufacturing & GLP toxicology studies | $4 Million | 2026 |
| 3. | Phase II clinical trials | $4 Million | 2027 |
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